> EDIT: The mRNA vaccines are obviously not therapeutic antibodies, but they probably checked for cross-reactivity of the engineered spike protein as well as the generated antibodies using similar methods. I’m not 100% sure, though.

There is a study[0] showing cross-reactivity between SARS-CoV-2 antibodies and other human tissues, thus predisposing the host to autoimmune diseases. This should apply even more so to any vaccine since vaccines produce a more robust immune response.

Phase 2/3 of Pfizer-BioNTech did, however, include people with autoimmune diseases [1]. Other vaccine trials did not, as far as I am aware. This does not really shine a light on pre-disposition to an autoimmune disease 6-9-12 mo down the road.

Reading this comment again before I post made me realize it sounds very gloomy, so I feel obliged to say I'll be getting whatever vaccine I can get my hands on at the soonest possible date.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246018/#__ffn_...

[1] https://www.fda.gov/media/144245/download

Thank you for the links! Here’s a review about autoimmunity in COVID-19: https://www.sciencedirect.com/science/article/pii/S089684112...

> There is a study[0] showing cross-reactivity between SARS-CoV-2 antibodies and other human tissues, thus predisposing the host to autoimmune diseases. This should apply even more so to any vaccine since vaccines produce a more robust immune response.

Since the antibody tested in the study was a commercial, monoclonal one, this is somewhat hard to assess. But I think you’re right given what they found in the blood tests.

> This does not really shine a light on pre-disposition to an autoimmune disease 6-9-12 mo down the road.

Autoimmune reactions should happen in the short run, right?

>Autoimmune reactions should happen in the short run, right?

I believe Pandermix took 6 months for narcolepsy to develop.

The important to thing to realize about Pandermix was that the rate of people impact was so small that even if we followed 50k phase 3 participants over 10 years, we wouldn't have uncovered the issue.

The narcolepsy issue was never going to be uncovered before it was rolled out large scale.

According to https://journals.plos.org/plosone/article?id=10.1371%2Fjourn...

the onset judged by "first contact to health care" was much earlier.

There seems to be an early-onset but also long-standing effect, maybe due to circulating antibodies inducing the autoimmune response over time.

This does not make sense to me. Your own antibodies triggering an autoimmune response ?

Why would you take the vaccine at the first chance you get ? what's the risk-benefit calculation you see in front of your eyes ?

Not OP, but I feel similarly. I'm going to go get the vaccine as soon as I can because what's the alternative? I want to go to concerts and travel again. If I don't get the vaccine my choices are: 1) not care and probably get COVID-19, which has a chance of developing the same autoimmune issues that have been discussed 2) hide in my room for another unspecified length of time.

It is at this point that I remind myself of all the other dangerous things that I do: driving, motorcycling, rock climbing, skiing, etc.

The risk of long term side effects is worth the benefit of spinning up the global economy again.

This is perfect thank you!!!