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Re:Anti-diarrhoea drug drives cancer cells to cell death by wittyreference on Wednesday December 23, 2020 @01:14PM (#25520336)
Opioids have already been studied regarding their neurotoxic effect. We already know they are neurotoxic. We already know they use the ATF4 pathway. Loperamide is an opioid.

It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis.

Re:Anti-diarrhoea drug drives cancer cells to cell death by Supermancho on Wednesday December 23, 2020 @01:32PM (#25520540)
> It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis.

More likely it's a liability check. The null hypothesis characterization is incidental.