Re:Anti-diarrhoea drug drives cancer cells to cell death
by wittyreference on Wednesday December 23, 2020 @01:14PM
(#25520336)
Opioids have already been studied regarding their neurotoxic effect. We already know they are neurotoxic. We already know they use the ATF4 pathway. Loperamide is an opioid.
It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis.
Re:Anti-diarrhoea drug drives cancer cells to cell death
by Supermancho on Wednesday December 23, 2020 @01:32PM
(#25520540)
> It's like a study finding that "opioid X" gets you high via mu-opioid receptors. It's not really a finding; it's the null hypothesis.
More likely it's a liability check. The null hypothesis characterization is incidental.
Probably because it's what they were studying which led to the analysis? A drug doesn't have to be unique to be important in understanding side effects...or off-label use if that's how you want to think of it.
Getting funding to study all of them at once is more challenging, so it shouldn't be a surprise that it's constrained to one.