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A comment on Anti-diarrhoea drug drives cancer cells to cell death. Parent comment

Re:Anti-diarrhoea drug drives cancer cells to cell death by Scoundreller on Wednesday December 23, 2020 @11:43AM (#25519424)
> the way to bypass the liver is to use suppositories

Or transdermal or intranasal or sublingual or through the lungs or ...

But I think the issue here is that the blood-brain barrier is actively pumping it back out, not immediate liver metabolism.

I’ve updated my post a bit. I probably shouldn’t have said “locally” since it gets into the bloodstream and should have an effect from the other side too.

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Re:Anti-diarrhoea drug drives cancer cells to cell death by elmolino89 on Wednesday December 23, 2020 @12:26PM (#25519864)
0.3%. this is what according to Wikipedia you get in the bloodstream after the oral dose.

Blood-brain barrier is another obstacle to cross. Quinidine taken with loperamide blocks transport protein P-glycoprotein and causing loperamide to have opioid like effects in the brain.

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