Re:Anti-diarrhoea drug drives cancer cells to cell death
by Scoundreller on Wednesday December 23, 2020 @11:43AM
(#25519424)
> the way to bypass the liver is to use suppositories
Or transdermal or intranasal or sublingual or through the lungs or ...
But I think the issue here is that the blood-brain barrier is actively pumping it back out, not immediate liver metabolism.
I’ve updated my post a bit. I probably shouldn’t have said “locally” since it gets into the bloodstream and should have an effect from the other side too.
Re:Anti-diarrhoea drug drives cancer cells to cell death
by elmolino89 on Wednesday December 23, 2020 @12:26PM
(#25519864)
0.3%. this is what according to Wikipedia you get in the bloodstream after the oral dose.
Blood-brain barrier is another obstacle to cross. Quinidine taken with loperamide blocks transport protein P-glycoprotein and causing loperamide to have opioid like effects in the brain.
If a drug is metabolized in the liver then instead of ingesting a bottle of pills (most likely not safe, certainly not recommended), the way to bypass the liver is to use suppositories. Again, safety-wise it is not a sensible thing to do.