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A comment on mRNA's next challenge: Will it work as a drug?. Parent comment

Re:mRNA's next challenge: Will it work as a drug? by aazaa on Friday December 18, 2020 @04:58PM (#25472585)
Some clinical work has been done with mRNA vaccines as treatments for other diseases, including cancer. Nothing has made it to Phase 3 yet (other than for Covid-19), but on this page you'll find links to a slew of clinical trials over the years.

https://www.modernatx.com/pipeline/modernas-mrna-clinical-tr...

A handful of studies are currently recruiting for Phase 2, so that means there was a successful Phase 1 some years ago. So those people would, I believe, be the longest-surviving patients to have received an mRNA vaccine.

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Re:mRNA's next challenge: Will it work as a drug? by divbzero on Friday December 18, 2020 @07:58PM (#25473965)
Yes, and also a number of non-Moderna clinical trials dating back to 2008. [1] The largest of those trials enrolled around 200 participants — not Phase 3 sized but still significant.

[1]: https://www.nature.com/articles/nrd.2017.243/tables/2

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Re:mRNA's next challenge: Will it work as a drug? by Scoundreller on Friday December 18, 2020 @05:15PM (#25472747)
The Phase 1 study might just mean it didn’t immediately harm the people that got it.

They might be followed closely for a long time; but it may only be a handful of people too.

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Re:mRNA's next challenge: Will it work as a drug? by dharma1 on Saturday December 19, 2020 @07:20AM (#25476988)
Which companies besides Moderna are at/near phase 2 for vaccines against other diseases now?
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