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Re:FDA authorizes rapid, at-home coronavirus test by ineedasername on Wednesday December 16, 2020 @12:15PM (#25445150)
On a large scale, the wrong results from such tests don't matter if you test people often enough

That assumes that for each test it is a sort of dice roll on whether or not there will be a false result. It might be that something about the individual person's biochemistry or health history (like prior exposure to a different corona strain) is the cause of the false result. If that's the case, then people who receive a false result on this type of test will tend to always receive false results, and testing more often won't help much.

Re:FDA authorizes rapid, at-home coronavirus test by spion on Wednesday December 16, 2020 @12:31PM (#25445414)
Its the viral load, or the amount of virus, mainly. Most people have a large viral load when they are the most infectious, especially in the nose and throat. Testing daily would ensure that you know immediately when you're highly infectious.

A recent check of the rapid test used in the UK is that its largely unaware of the virus if the necessary PCR cycles are > 25, gets it right half of the time for CT between 20 and 25 and it gets very good if viral load is large enough to be detected by < 20 cycles. Other rapid tests are AFAIK somewhat better.

The main problem that most (western) countries failed to solve is to remove reasons to not take a test and not to self-isolate, and that's primarily inability to get proper support WRT work / monetary situation while self-isolating.

Make it easier for people to self-isolate than not to, and people will do it.

Re:FDA authorizes rapid, at-home coronavirus test by anon946 on Wednesday December 16, 2020 @12:29PM (#25445391)
If the goal is to lower Rt to below 1, however, it still may be acceptable. See:

https://advances.sciencemag.org/content/early/2020/11/20/sci... https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v... (preprint of above)

Re:FDA authorizes rapid, at-home coronavirus test by pas on Wednesday December 16, 2020 @02:28PM (#25447297)
They can simply use a different test. It'd be much more resource efficient to use the rapid tests on those for whom it works as intended and use PCR (molecular) tests for those who get false positives every time.

I have friend who has a colleague who always produces a false pos. antibody test. They know it, they still test him. (At this point basically to make sure the test does something at all.)

After all, every kind of proactive/preventive measure helps a bit to keep a group/family/workplace safe.

Re:FDA authorizes rapid, at-home coronavirus test by ineedasername on Wednesday December 16, 2020 @08:53PM (#25451385)
Yep, if we can distinguish between who it does and does not work as intended. How do you verify a false positive? By performing a better test, but then you have to do it for everyone and we're back to square one. However I agree with other comments that even with false results, it's still very useful, just that frequent testing won't necessarily overcome all false results.
Re:FDA authorizes rapid, at-home coronavirus test by account42 on Thursday December 17, 2020 @06:06AM (#25454482)
> but then you have to do it for everyone

Unless you are also worried about false negatives you only need to perfrom the better test on those that reported positive on the quicker test.

Re:FDA authorizes rapid, at-home coronavirus test by ineedasername on Thursday December 17, 2020 @10:53AM (#25456651)
Sure I'd be worried about false negatives. Identifying the infected to allow them to isolate is the reason for it. I'm not worried about false positives because there is little harm done in having someone isolate uneccessarily. Much more harm is possible by keeping an infected person, who now thinks they're fine, out in public.
Re:FDA authorizes rapid, at-home coronavirus test by pas on Friday December 18, 2020 @03:54AM (#25465170)
These assays are very skewed toward producing false positives.

Exactly for this reason.

It's not perfect. PCR can miss the early stages of the infection too.

These are just signals.

Luckily we know that viral load is the factor for transmission rate (infectiousness). So even if someone is (false) negative, but has symptoms, should self-quarantine.

Re:FDA authorizes rapid, at-home coronavirus test by jborichevskiy on Thursday December 17, 2020 @12:43AM (#25452917)
You corrected some misconceptions I had about how straightforward things are