In general, combining drugs is a bit like playing Russian Roulette. Very few such combinations have been thoroughly studied (or sometimes not studied at all), so people rarely have any idea what effects these combinations will have long-term, or sometimes even short term.

Mostly, people take them based on rumors, hearsay, and anecdotes, which is kind of sad. They've heard some random guy on the internet say it was a good combo, or their buddy told them it worked for them, and somehow in their mind that makes it a good idea to try it.

Given ~15 years of experience using it in myself and many friends I would bet big money piracetam makes a huge difference (in many situations, not just MDMA) and usually is a great thing to combine with anything (I don't know if it's always the case though, perhaps there is a combination which may be deadly) and it's been invented half a century ago but FDA wouldn't even bother to approve it safe, let alone useful.

I wish some scientists could go through all the reports found on the Internet and study every one of repeatedly described effects.

Which is not necessarily bad. They might schedule it as a prescription drug (as in many, although not in all countries) if they confirmed it works.

Basically take 2 grams or more a day for a few weeks then stop for a day and try E .

Dont take back with mdma since it seems to reduce some of the good effects

By the way it's worth mentioning NAC is the same exact substance like in the ACC cough pills but can be bought in bulk powder 10 times cheaper.

Many people take it (as an extremely potent antioxidant) regularly but it's not clear if prolonged supplementation can prevent cancer or cause it.