Given ~15 years of experience using it in myself and many friends I would bet big money piracetam makes a huge difference (in many situations, not just MDMA) and usually is a great thing to combine with anything (I don't know if it's always the case though, perhaps there is a combination which may be deadly) and it's been invented half a century ago but FDA wouldn't even bother to approve it safe, let alone useful.

I wish some scientists could go through all the reports found on the Internet and study every one of repeatedly described effects.