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A comment on Pfizer Covid vaccine approved for use next week in UK. Parent comment

Re:Pfizer Covid vaccine approved for use next week in UK by eastendguy on Wednesday December 02, 2020 @05:36AM (#25275186)
Well, fwiw, the inventor of the mRNA vaccine idea, Ingmar Hoerr, thinks side effects are very unlikely, since the mRNA molecules dissolve after a few days. He has been working on this for 20 years, with no serious side effects ever observed.

https://en.wikipedia.org/wiki/Ingmar_Hoerr

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Re:Pfizer Covid vaccine approved for use next week in UK by Scaevolus on Wednesday December 02, 2020 @08:59AM (#25276358)
There _are_ acute side effects, basically equivalent to a strong viral effection. I agree that long term side effects are unlikely.

https://www.nejm.org/doi/full/10.1056/NEJMoa2022483

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Re:Pfizer Covid vaccine approved for use next week in UK by stjohnswarts on Wednesday December 02, 2020 @08:23PM (#25284113)
*possible, and in low % of people, and none have been shown to be more than a few days.
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Re:Pfizer Covid vaccine approved for use next week in UK by Scaevolus on Friday December 04, 2020 @12:37PM (#25305255)
A lot of these side-effects affect >50% of people (phase 3 dosage is 100ug), including fatigue, chills, headache, muscle pain, nausea, and pain.

100% of the 100ug treatment group had at least one symptom, 80% of those classified as moderate. The vaccine is going to make you feel sick for a little while.

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Re:Pfizer Covid vaccine approved for use next week in UK by john_alan on Wednesday December 02, 2020 @05:59AM (#25275298)
Was the SARS vaccine virus not mRNA?
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Re:Pfizer Covid vaccine approved for use next week in UK by apexalpha on Wednesday December 02, 2020 @06:51AM (#25275538)
Yes, this is why these mRNA vaccines are here so fast; a lot of prework was done for SARS vaccine, which is also a Corona disease.

But I think SARS died out before the vaccine was ready/needed.

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Re:Pfizer Covid vaccine approved for use next week in UK by patall on Wednesday December 02, 2020 @07:29AM (#25275744)
the parent is concerned regarding the appearance of ADE (Antibody-dependent enhancement) during the creation of the SARS vaccine.

While we cannot totally disregard ADE, I assume we should have seen it by now (and the Oxford trial was stopped exactly because they thought they might have observed something like it). Whether it appears again on a population scale level, nobody knows.

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Re:Pfizer Covid vaccine approved for use next week in UK by jonstaab on Wednesday December 02, 2020 @04:30PM (#25281902)
I don't know anything, but I've read that ADE can take 1-3 years to surface.
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Re:Pfizer Covid vaccine approved for use next week in UK by SomeoneFromCA on Wednesday December 02, 2020 @11:33AM (#25278047)
Yeah, I've thought about it too, but both mild reinfections and vaccine trials show that SARS-2 does not exhibit ADE.
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