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Re:Compound found in the hallucinogenic tea ayahuasca can gr... by hx2a on Sunday November 29, 2020 @09:42PM (#25250250)
There was a relevant conversation on HN about this over a year ago that you might be interested in:

How do people learn to cook a poisonous plant safely?

https://www.bbc.com/news/business-48859333

https://news.ycombinator.com/item?id=20874912

Bottom line, it is trial and error, an evolution of ideas and culture over many generations.

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