How much this matters is open to debate, but base 10 is clearly a terrible thing in this. It might be a good compromise, but I am not sure.
Obviously multiplying and dividing by 5 and 10 are more natural in a base 10 system, but dividing things in halves, quarters, etc. (or multiplying by powers of two) are a much more common operation. (We only think of 10s as round numbers because of the base-10 decimal system.)
12 is useful in that it has so many different factors, but it misses all the benefits of being a power of 2, so I feel 8 is superior. Hexadecimal also has benefits, but my feeling is that 16 symbols would be too many for everyday use. Difficult to count on fingers and such. 8 really seems ideal to me. In fact, I've mused in the past that it's kind of a shame - you can imagine a world where people ignored their thumbs when finger counting and just lucked into a base-8 system thousands of years ago. (Although of course in that case we wouldn't call it base-8, it'd be base-10!)
What a fascinating hypothetical!
But to the main topic - sorry to be dense about it, but I'm actually just not used to the imperial system. Which parts of it are easy to manipulate in this way? I know there are 12 inches in a foot but that's the only "easy" conversion I remember off the top of my head.
Anyway, I'm not really arguing for the imperial system, just saying that aside from legacy use, that's the one advantage I see for it vs metric. But a metric system based on base-eight... that would be beautiful.