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Re:macOS unable to open any non-Apple application by olivierlacan on Thursday November 12, 2020 @04:58PM (#25075671)
Add ocsp.apple.com to your Pi-Hole blocklist if you have one and the issue goes away.

You can also add this to your /etc/hosts file:

0.0.0.0 ocsp.apple.com

Re:macOS unable to open any non-Apple application by gitweb on Thursday November 12, 2020 @09:49PM (#25078245)
At that point might as well get rid of the Mac and switch to something else.
Re:macOS unable to open any non-Apple application by sxates on Thursday November 12, 2020 @06:46PM (#25076917)
Insta-add to pi-hole. Interesting though, that in my query log I don't actually see my machine trying to hit this domain when I open apps.