Without an encapsulation mechanism, I do not consider using newtypes to wrap real numbers with units of measure sufficient to be called “type safety”; in my experience it still requires significant discipline to use properly (because the points of wrapping/unwrapping are usually fairly local and require delicate care).

Of course, this is a matter of both subjective definition and relative situation. One can theoretically imagine a codebase that conventionally uses units-of-measure wrappers so pervasively that the safety is genuine, since the places where values are wrapped/unwrapped are so well-defined that any misuse would stick out as wrong. However, I have never in my life seen such a codebase, so anecdotally I can only consider such measures more like the lines painted on a road to delineate lanes than a bona fide safety mechanism.

On one hand, yes. On another, no. I am working right now on a Go codebase with lots of newtypes (well, the Go's equivalent), and they're generally casted to/from underlying primitive types basically in two places: when they're serialized into JSON, and where they're deserialized from JSON. And in several places in the middle of the code where you need an explicit cast, well, the cast is explicit. You actually have to consider it.

Mind you, in Go it's almost impossible to hide the newtype's constructor unless you jump through some rather unintuitive hoops. Is Go fundamentally type-unsafe? I don't think it is, although I sometimes wish some structs were impossible to zero-initialize. Then again, that's generally amended by unexporting the struct and exporting its interface instead.

Interface{} and nil pointers point to yes.

In everyday language a downcast, even a checked one, is not a type-safe operation, and so to the extent that Go's limited type system makes it impractical to write programs without downcasts I'd say that Go is fundamentally type-unsafe.

    defer func() {
        if e := recover(); e != nil {
            fmt.Printf("not a string %v\n", e)
        }
    }()
    v := interface{}(5)
    u := v.(string)
    fmt.Println(u)

Normally one would say a checked downcast like that is not type-safe, because you can't reason locally about the type behaviour of the downcast based on knowing the type of v. You would have to know the value of v, which is a Turing-complete problem in the general case.