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Re:Pyston v2: Faster Python by samcolvin on Wednesday October 28, 2020 @04:48PM (#24923966)
Victor Stinner (Python core developer focused on performance) has a great speech about this question:

There are a lot of reasons actually

- Performance limited by old CPython design. If you fork it you have to deal with all the legacy code.

- CPython is limited to 1 thread because of the GIL.

- Specific memory allocators, C structures, reference counting, specific garbage collector etc.

You can find that video in here: https://youtu.be/TXRPCZ7Nmh4

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