I am not making any unprovable claims about a spirit/soul, though I do not completely shut out the possibility there is something we haven't measured yet. I believe that externally, there is no difference in your scenario.
I think where there might be a difference, is to the consciousness itself. The continuity of that experience being the difference. In which case, gradually replacing the brain should be a solution to the continuity problem (like the Ship of Theseus). Where I think this is conceptually weakest, is when considering how much continuity of consciousness exists while sleeping or being sedated.
What is the point of information if you can't embody it? I guess the desirability of immortality in a computer system completely relies on how faithfully the system can pretend on your behalf, that you have a body. An endless heaven without having a body to structure your sensations and grant you movement through space and time... seems lacking.
Separately: There's no point in my life where I'm ever the same person. I've continually evolved.
With human history, the resolution of records continues to expand. Fossils, artifacts, writing, photos, and Google search logs all contain personal information. The resolution of historical information shows a clear trend.
Am I immortal if only a moment of my life is preserved, or am I immortal if all points of my life can be accurately be resimulated?
I would argue there is no difference. In order to resimulate me at any point in time, my context, my surroundings, must be considered. My context exists for historic reasons. In order for my brain to be interpretable its application in real world interactions must be considered the the world can only be understood by knowing its history.
To know me you need to know my life and surroundings at all points in time. Technology is slowing increasing the resolution of human immortality, although the universe seems to have already accomplished this perfectly.
https://en.wikipedia.org/wiki/Ship_of_Theseus
Even without your previous experience, you are literally not the same cells that you were a few years ago. As such, to achieve the same kind of continuity of consciousness and become fully digital, I think one would have to gradually replace their brain.