There are some significant differences. For example, strollers can get up a step, and you can potentially take the little passenger out and carry them and their stroller over uneven ground or up a set of steps. In a wheelchair, you don't have those kinds of options, so the availability of alternative access via ramps and lifts (elevators) is much more important.

With lots of stroller experience but no wheelchair experience, I’m pretty sure they’re different.

I can readily scale a curb or pair of steps with a stroller in a way that a wheelchair user cannot (or can only with difficulty/risk).