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A comment on From its name to its drug interactions, there’s a lot going on with grapefruit. Parent comment

Re:From its name to its drug interactions, there’s a lot goi... by cowboysauce on Wednesday October 07, 2020 @02:39PM (#24711244)
The lemon-tek method of consuming psilocybin mushrooms isn’t related to this. Acidic conditions speed up the conversion of psilocybin into psilocin. This normally happens in your stomach, the lemon-tek method just does externally. This causes the overall experience to be shorter, but more intense. Psilocin also doesn’t appear to be metabolized by the enzymes that grapefruit inhibits.
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Re:From its name to its drug interactions, there’s a lot goi... by SirLuxuryYacht on Wednesday October 07, 2020 @05:09PM (#24712756)
source?
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Re:From its name to its drug interactions, there’s a lot goi... by cowboysauce on Friday October 09, 2020 @10:24AM (#24730185)
The wikipedia article for Psilocybin has all of the above.

>Psilocybin [...] is a prodrug that is converted into [...] psilocin [...] This chemical reaction takes place under strongly acidic conditions

And for metabolism

>Psilocin is broken down by the enzyme monoamine oxidase [...] Some psilocin is not broken down by enzymes and instead forms a glucuronide [...] Psilocin is glucuronated by the glucuronosyltransferase enzymes UGT1A9 in the liver, and by UGT1A10 in the small intestine

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