From its name to its drug interactions, there’s a lot going on with grapefruit

Re:From its name to its drug interactions, there’s a lot goi... by dfalzone on Wednesday October 07, 2020 @12:25PM (#24709807)

I wonder if this is at all related to the common pairing of citrus fruits with psychedelic drugs. A lot of people recommend eating an orange or drinking orange juice when you take LSD, and a lot of people recommend using lemons to enhance psilocybin mushroom trips. Maybe grapefruit would pair even better with these drugs.

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Re:From its name to its drug interactions, there’s a lot goi... by cowboysauce on Wednesday October 07, 2020 @02:39PM (#24711244)

The lemon-tek method of consuming psilocybin mushrooms isn’t related to this. Acidic conditions speed up the conversion of psilocybin into psilocin. This normally happens in your stomach, the lemon-tek method just does externally. This causes the overall experience to be shorter, but more intense. Psilocin also doesn’t appear to be metabolized by the enzymes that grapefruit inhibits.

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Re:From its name to its drug interactions, there’s a lot goi... by SirLuxuryYacht on Wednesday October 07, 2020 @05:09PM (#24712756)

source?

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Re:From its name to its drug interactions, there’s a lot goi... by cowboysauce on Friday October 09, 2020 @10:24AM (#24730185)

The wikipedia article for Psilocybin has all of the above.

>Psilocybin [...] is a prodrug that is converted into [...] psilocin [...] This chemical reaction takes place under strongly acidic conditions

And for metabolism

>Psilocin is broken down by the enzyme monoamine oxidase [...] Some psilocin is not broken down by enzymes and instead forms a glucuronide [...] Psilocin is glucuronated by the glucuronosyltransferase enzymes UGT1A9 in the liver, and by UGT1A10 in the small intestine

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Re:From its name to its drug interactions, there’s a lot goi... by cyberbanjo on Wednesday October 07, 2020 @12:35PM (#24709932)

Grapefruit juice also has drug interactions with opiates and (I think) anti depressants, amongst other things.

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Re:From its name to its drug interactions, there’s a lot goi... by TT3351 on Wednesday October 07, 2020 @06:03PM (#24713299)

Certainly reminds me of the Kool Aid in "Electric Kool Aid Acid Test"

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