From its name to its drug interactions, there’s a lot going on with grapefruit

Re:From its name to its drug interactions, there’s a lot goi... by jalk on Wednesday October 07, 2020 @07:13AM (#24707088)

> the manufacturer recommends starting with 6mg and ending up anywhere from 0.5 to 10mg depending on the patient's response

I tried to explain binary search to my gp when she was trying to find my dose of thyroxin. Unfortunately, according to her, a too high does carries a lot of unpleasant side effects - so linear search it was.

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Re:From its name to its drug interactions, there’s a lot goi... by vikramkr on Wednesday October 07, 2020 @09:41AM (#24708050)

Yeah, binary search where you don't know what the upper bound is with a narrow therapeutic index drug is not necessarily the best option

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Re:From its name to its drug interactions, there’s a lot goi... by buddhiajuke on Wednesday October 07, 2020 @09:47AM (#24708129)

We pretty much did binary search to find my lithium levels. The lethal concentration of lithium is very close to the therapeutic range, but we couldn’t afford to spend long on low doses (since you have to take blood tests to assess effective dosages.)

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Re:From its name to its drug interactions, there’s a lot goi... by krageon on Thursday October 08, 2020 @07:13AM (#24717998)

If you keep a good diary you can limit the blood tests to 1-2 times per year and assess therapeutic effect using self-reporting.

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