I don't think that's true of The Selfish Gene (and even more so for its successor, The Extended Phenotype, as one can tell just from the title). It seems to me to be a serious work on evolutionary biology.
It's not that it isn't serious. Pop science doesn't have to be BS. But it often risks conveying to readers that they have a better grounding than they actually have, which The Selfish Gene has also done. Pop science books are good ways to attract young readers to the sciences and to keep older readers engaged in it, but they are not in and of themselves contributions to the field.
Edit: to go back to original article: memorising the stuff in detail isn't hugely useful -- it's a useful jumping off point to investigate in more detail, but the books basic ideas are easily understood, that's the point
I feel like he's looking at this through the prism of his speciality (producing interactive learning materials), and by doing that has missed the point a little bit. He's looking a genre of books at if they're a different thing to what they actually are, it's the wrong level.
I get reading a book once doesn't translate directly to "facts retained in memory" whereas his idealised new form of media does. But as you say, his examples are edutainment. I feel like what he's suggesting only usefully applies to either textbooks (which he's separated off into a different category anyway) or to a situation where the aim is to memorise as much as possible in a single reading. Which is fine! But it doesn't really need to happen for pop science -- just getting the general gist of an idea across in an entertaining package is okay.