On Acer Nitro 5 with Nvidia GTX-1060Ti and i5, stock Ubuntu 20.04 loaded no problems, and even DisplayLink driver for dual monitor, one through regular HDMI + other through USB -> HDMI adapter worked (though I couldn't get it to rotate display vertically).
The bugs I did have were with it constantly re-disovering network printers that I had to disable, and changing the default wifi power-saving settings because something was funky with it.
On Asus TUF A15 with Nvidia RTX-2060/AMD Renoir + AMD Ryzen 7 4800h absolutely no distro worked out-of-the-box and I needed mainline kernel + latest Nvidia drivers. But after fixing that myself Pop_OS picks up everything perfectly and no problems.
Both of them have CUDA working IIRC (at least running "nvidia-smi" says it does).
I have heard great things about Pop and I am going to be building a new machine with these new cards and giving pop a try.
Honestly, to me that's not a big sell lol. And probably not to the type of people that like distros like Arch. We just want nivida to work like AMD and mesa drivers do. (Having done some testing, I am able to squeeze more performance out of a distro that builds up, such as Arch, vs a distro that you take down, like Ubuntu).
Not sure how easy it is to actually game on it though, haven't tried yet. For everything else however, Manjaro is an extremely solid choice, with a very recent kernel too.