Python always has had a few really strong killer apps. In the past stuff like Zope (GvR himself worked for a few years on this, and it's still around), and more recently things like Django, numpy, scipy, matplotlib, PyTorch or open scientific computing in general.

Python seems like a very popular choice when the time comes to replace bash or perl scripting from the 90s. Oodles of internal tooling and OS tools in the Linux space use it.