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A comment on Ask HN: What are some available force multipliers that most people don't know?. Parent comment

Re:Ask HN: What are some available force multipliers that mo... by btrettel on Sunday August 09, 2020 @09:40AM (#24099569)
I'd recommend against regularly taking anticholinergic drugs like diphenhydramine because they've been fairly clearly linked to cognitive decline in the elderly when taken regularly: https://en.wikipedia.org/wiki/Diphenhydramine#Adverse_effect...

It's worth noting that many allergy meds (like diphenhydramine) are anticholinergic, but only ones which pass the blood-brain barrier are linked to cognitive decline. So newer allergy meds like cetirizine and loratadine are better.

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Re:Ask HN: What are some available force multipliers that mo... by esperent on Sunday August 09, 2020 @10:18PM (#24104838)
Your link says anticholinergic use later in life has been linked to cognitive decline, not that use by young people results in cognitive decline later in life.
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Re:Ask HN: What are some available force multipliers that mo... by btrettel on Monday August 10, 2020 @07:29AM (#24108079)
I linked to Wikipedia, but I originally read the abstract of a different study, which might have examined diphenhydramine specifically rather than many anticholinergic drugs. The abstract of the article cited on Wikipedia makes it clear that it's a cumulative effect, and that they studied outcomes in older adults. So I think Wikipedia describes the research incorrectly.

https://pubmed.ncbi.nlm.nih.gov/25879993/

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