>>>This might sound very harsh, but it's important to get this right early, as one bad decision here is usually irreversible.

Nothing in software is irreversible

>>Godot doesn't display native widgets, so it has no support for accessibility,

Then it would be better to evangelize adding accessibility support into Godot.

>If you want to use this in a business, either for an internal tool or for an application you sell, this is a horrible idea. There are some laws mandating accessibility, a

That largely depends on the type of application and the target. There are some LOB applications that would never need accessibility because the jobs they are for require sight and/or hearing for safety reasons. For example if you are building a LOB application that is used on Factory floor with large machinery