Could you have a very high-tech civilization based on biological manipulation?
Biological structures are extremely efficient and strong and hearty at the molecular level.
It might not be "industrial" in the mining/cement/roads sort of sense.
The only exception would be if for some reason they could not follow our path of technological development. For example if a marine species developed intelligence, they obviously could not easily utilize fire, which in turn would make any advancements in metallurgy nearly impossible. If you can't readily smelt large amounts of steel, of course you can't produce large quantities of reinforced concrete. Under such a circumstance, biological manipulation may be the only way to produce many things we take for granted. However this would require the devlopment of biological manipulation technologies without utilizing those other "conventional" technologies, which very likely isn't possible in practice.