> “Estrogen is not a treatment for ODD. I can’t be more emphatic about that,” McGough said. “You won’t find a reference anywhere that supports the use of estrogen for ODD.”
There's no way this was medically approved.
Now, it didn't work in our case because of underlying psychosis, which also means it's dangerous as heck and needs to be used carefully, but in terms of effect size, someone can go from rating their depression as 10 out of 10 down to zero in one treatment.
So I wouldn't be hasty to discard it, just careful to use it on the right people and maybe I'd figure out some way to deal with the psychosis so that those who might otherwise get excluded could have the benefits too.
So cracking a sarcastic joke, a thing that really only works if you know your audience and your audience knows you, feels safe, but obviously doesn't work very well.