Haven't used AutoCAD in anger for a while, but my default rest position on the keyboard is still fingers over Esc, thumb over space. I always preferred using the command line. Not out of some 'power user' power trip, but more for screen space and efficiency. Being able to use AutoLISP was pretty neat too.
Edit: Forgot the AutoCAD command line. You can still turn that on too, and type commands like it's the 80s. It's actually kind of a paragon of a mature product that maintains all its older interfaces.