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Re:Increase in delirium, rare brain inflammation and stroke ... by oillio on Tuesday July 07, 2020 @11:58PM (#23766767)
There has been reports of blood related complications with COVID infections; inflammation and blood clots. Anecdotal, but here is one case:

https://www.scmp.com/news/world/europe/article/3091949/coron...

And a Nature article with more information: https://www.nature.com/articles/d41586-020-01403-8

Obviously it is too soon to tell, but this may be more of the same. It is concerning because we expect a large number of people to be exposed to this virus. Even a small chance of long term damage ends up with a lot of cases with the numbers we are expecting.

Additionally, it may change the calculus of so called herd immunity strategies. Though it is a little late for that.

Re:Increase in delirium, rare brain inflammation and stroke ... by __blockcipher__ on Wednesday July 08, 2020 @12:46AM (#23766971)
FWIW, blood clotting, strokes, etc are known complications of pathological cytokine release syndrome, and we see these same symptoms occurring in other diseases like Influenza.

Unfortunately there is a huge faction of people who seek to selectively represent facts to promulgate the narrative that SARS-CoV-2 is unusually dangerous, which as far as I can tell is just completely false.

SARS-2 is a great spreader and a very poor killer. Those interested in learning about hoe it spreads might find some of the research findings around interferon-mediated early course immunosuppression interesting. IMO it is a plausible mechanism for why SARS-2 exhibits PRE-symptomatic spread (not asymptomatic).

BTW the above (great spreader, with outcomes overwhelmingly positive) is precisely why I think SARS-2 was the worst possible candidate to respond to with a “lockdown”. It really saddens me to see destructive and unethical measures paraded as “common sense”, when they’re anything but. [/rant]

Re:Increase in delirium, rare brain inflammation and stroke ... by FuckButtons on Wednesday July 08, 2020 @01:46AM (#23767228)
A preprint I was reading yesterday noted an 8 fold increase in risk of stroke in COVID patients vs severe flu patients. COVID is dangerous, it’s not the flu, but nor is it the Black Death. It’s far more dangerous for the elderly than flu. But more importantly for everyone else, Lock downs are a response not to the individual risk of the disease but to the collective risk of not having a functioning healthcare system.
Re:Increase in delirium, rare brain inflammation and stroke ... by s1artibartfast on Wednesday July 08, 2020 @02:37AM (#23767475)
>A preprint I was reading yesterday noted an 8 fold increase in risk of stroke in COVID patients vs severe flu patients.

The problem I have with these statement is the lack of context. Does the additional risk of stroke in COVID patients meaningfully impact the overall risk profile? If an elderly person has say a X% chance of death from COVID, and a 0.00X% of stroke, news reporting on this for public consumption is just fear mongering.

Re:Increase in delirium, rare brain inflammation and stroke ... by scarmig on Wednesday July 08, 2020 @05:04AM (#23768187)
SARS-CoV-2 has an IFR that's ~5x that of regular flu and spreads significantly faster.

It's worth pointing out that it's killed more people than all natural disasters and terrorist attacks in the US combined. So if COVID-19 is a poor killer, so were Osama bin Laden and Hurricane Katrina.

And that's with the lockdowns. Without them, we'd probably be at half a million deaths by now. The lockdowns also bought us time to develop more effective treatment strategies.

Re:Increase in delirium, rare brain inflammation and stroke ... by fzeroracer on Wednesday July 08, 2020 @01:40AM (#23767198)
I'm saddened to see people on HN selectively represent facts to try and spread the narrative that SARS-CoV2 isn't very dangerous. Which as far as I can tell is just completely false.

The reality is that it is in fact dangerous. People try to point to the idea that it only kills a low percent of the population and not putting into perspective that a disease killing around 1% or so of all humans would be a rather big deal.

Re:Increase in delirium, rare brain inflammation and stroke ... by depressedCorgi on Wednesday July 08, 2020 @10:11AM (#23770022)
I completely agree. I don’t understand why people aren’t taking this seriously. I have COVID-19 right now and it’s awful. I’m a healthy 32 year old and I’ve been lying in bed for 4 days and I only have what I think is mild symptoms. I can easily see how if I had a pre-existing condition or was unhealthy that it could kill me. I think the problem is that some people don’t believe it until the see or they just don’t care. It’s so sad. I work at a Starbucks and people come in everyday without a mask and are offended when we tell them to wear one, and it’s for their safety!
Re:Increase in delirium, rare brain inflammation and stroke ... by thu2111 on Wednesday July 08, 2020 @10:19AM (#23770089)
How can you argue that it's dangerous when the scientific evidence is so overwhelmingly to the contrary?

Your entire post contains many unsubstantiated beliefs:

- Nobody is arguing the death rate is 1% anymore, that number is far, far too high. Apparent IFRs have been constantly falling and even the CDC - quite incentivised to support panic given their actions so far - now say it's around the level of seasonal flu.

- The idea that the virus would infect 100% of all humans alive isn't based on any actual real disease. No disease ever known has infected literally everyone on the planet.

There is huge amounts of data showing the virus isn't dangerous. People aren't "trying to spread a narrative". They're pointing out the real data on things like excess deaths, or the huge number who show mild symptoms.

Re:Increase in delirium, rare brain inflammation and stroke ... by Smithalicious on Thursday July 09, 2020 @03:59AM (#23777959)
Hundreds of thousands of people are dead
Re:Increase in delirium, rare brain inflammation and stroke ... by throwaway_pdp09 on Wednesday July 08, 2020 @04:59AM (#23768158)
I have to ask, should we e flag posts that say this IF they don't back it up with evidence?
Re:Increase in delirium, rare brain inflammation and stroke ... by jakeogh on Wednesday July 08, 2020 @05:04AM (#23768189)
Na. It's not against the rules, and it would be too much work for the mods if it was. Just point it out, and/or use the buttons. It's also a great source of prediction/assumption data... atleast for non-throwaway accts.
Re:Increase in delirium, rare brain inflammation and stroke ... by gridlockd on Wednesday July 08, 2020 @04:27AM (#23767993)
It is dangerous, but how dangerous?

Every year, about 1% of the population in the US dies. The median age of COVID deaths is above life expectancy. If you are elderly, death from pneumonia is quite likely even without COVID.

For a middle aged person, ordinary Influenza is statistically more dangerous than COVID. For a child, Influenza is vastly more dangerous. Efficacy of Influenza vaccination varies seasonally and averages around 50%.

Furthermore, COVID death rates are going down across the board, even while cases are rising.

Re:Increase in delirium, rare brain inflammation and stroke ... by DanBC on Wednesday July 08, 2020 @05:12AM (#23768224)
> Every year, about 1% of the population in the US dies. > The median age of COVID deaths is above life expectancy. If you are elderly, death from pneumonia is quite likely even without COVID.

People using the "they were going to die anyway" argument need to explain why they didn't die last year, or next year, but died this year, and died in huge numbers. Excess mortality is pretty high.

Research tells us people are dying more than 10 years early.

https://wellcomeopenresearch.org/articles/5-75

> Results: Using the standard WHO life tables, YLL per COVID-19 death was 14 for men and 12 for women. After adjustment for number and type of LTCs, the mean YLL was slightly lower, but remained high (13 and 11 years for men and women, respectively). The number and type of LTCs led to wide variability in the estimated YLL at a given age (e.g. at ≥80 years, YLL was >10 years for people with 0 LTCs, and <3 years for people with ≥6).

> Conclusions: Deaths from COVID-19 represent a substantial burden in terms of per-person YLL, more than a decade, even after adjusting for the typical number and type of LTCs found in people dying of COVID-19. The extent of multimorbidity heavily influences the estimated YLL at a given age. More comprehensive and standardised collection of data on LTCs is needed to better understand and quantify the global burden of COVID-19 and to guide policy-making and interventions.

Re:Increase in delirium, rare brain inflammation and stroke ... by gridlockd on Wednesday July 08, 2020 @06:08AM (#23768484)
> People using the "they were going to die anyway" argument need to explain why they didn't die last year, or next year, but died this year, and died in huge numbers. Excess mortality is pretty high.

That's not the argument I am making. A lot of older people indeed died sooner than they otherwise would have. COVID is statistically more dangerous to them than Influenza, but also COVID spreads more rapidly than Influenza in a population with zero immunity.

> Research tells us people are dying more than 10 years early.

This is significantly lower than the 2009 H1N1 pandemic, which averaged above 20 YLL per case:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792731/

This underlines my point that for younger age groups, COVID is statistically less dangerous than Influenza.

Again, the question is not whether COVID is dangerous. It certainly is. The question is, how dangerous?

Re:Increase in delirium, rare brain inflammation and stroke ... by jquery on Wednesday July 08, 2020 @10:53AM (#23770431)
If I’m reading your link right, it’s 22 years of life lost per 100,000, not per case. I could be misunderstanding.
Re:Increase in delirium, rare brain inflammation and stroke ... by gridlockd on Wednesday July 08, 2020 @01:57PM (#23772444)
They didn't give an average per case in this study, I arrived there by dividing the total amount of years lost by the amount of deaths (1,540/72 = 21.39).

That just happens to be close to the years lost per 100k.

Re:Increase in delirium, rare brain inflammation and stroke ... by emersonrsantos on Wednesday July 08, 2020 @01:00AM (#23767018)
Is this why they say nicotine may be a protective drug?

Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567056/

Re:Increase in delirium, rare brain inflammation and stroke ... by Scoundreller on Wednesday July 08, 2020 @09:51AM (#23769854)
It might be the smoke and not the nicotine.

Lots of non-smoking methods of getting nicotine that may not help.

And lots of ways of breathing in smoke that don’t involve nicotine.

Re:Increase in delirium, rare brain inflammation and stroke ... by emersonrsantos on Wednesday July 08, 2020 @01:19AM (#23767095)
Also, hidrohychloroquine downregulates interferon activation... too good to be true? https://academic.oup.com/rheumatology/article/59/1/107/55230...
Re:Increase in delirium, rare brain inflammation and stroke ... by throwaway_pdp09 on Wednesday July 08, 2020 @04:55AM (#23768142)
> to promulgate the narrative that SARS-CoV-2 is unusually dangerous

What is wrong with you? There is no evidence in your post to justify anything you say, you are either wishing things away or actively spreading FUD.

Flu: https://blogs.scientificamerican.com/observations/comparing-...

"The 25,000 to 69,000 numbers that Trump cited [as influenza deaths] do not represent counted flu deaths per year; they are estimates [...] In the last six flu seasons, the CDC’s reported number of actual confirmed flu deaths—that is, counting flu deaths the way we are currently counting deaths from the coronavirus—has ranged from 3,448 to 15,620, which far lower than the numbers commonly repeated by public officials and even public health experts."

> SARS-2 is a great spreader and a very poor killer

And actual mortality figures https://coronavirus.jhu.edu/data/mortality

> with outcomes overwhelmingly positive

Why the hell are you posting this? Your disinformation may contribute to people dying, are you ok with that? I'm all for contrarian views if they are backed up with evidence - so produce some.

Re:Increase in delirium, rare brain inflammation and stroke ... by jakeogh on Wednesday July 08, 2020 @05:11AM (#23768219)
CDC Influenza and pneumonia deaths by influenza season and age: United States, 2008–2015: https://www.cdc.gov/nchs/data/health_policy/influenza-and-pn... (these are not estimates, see the footnote)

  2015-2016
  Flu: 7,961
  Pneumonia: 131,858 
  All: 1,769,940
Excess deaths are all that really matters. Why not talk about those instead?
Re:Increase in delirium, rare brain inflammation and stroke ... by throwaway_pdp09 on Wednesday July 08, 2020 @05:20AM (#23768256)
Thanks for that. I don't understand the discrepancy between the article and the link you posted, however from your cite of 7,961 flu deaths (in the US) agrees with what the sciam article said.

> Excess deaths are all that really matters. Why not talk about those instead?

Good point, but I don't have them. What my and your posts seem to show is that flu is a heck of a lot less mortal than this covid. Which is the point.

Re:Increase in delirium, rare brain inflammation and stroke ... by jakeogh on Wednesday July 08, 2020 @05:41AM (#23768363)
NP. Regarding your last point, my understanding is the pneumonia deaths are on the same pdf because they are end game deaths from getting sick. Likely with one of the flu's. The COVID-19 death stats on the other hand, are inflated: http://v6y.net/1541e03e6cfd1442590bc7b5476f88c30a29a0d881bdb...

What really matters is excess deaths.

https://aspe.hhs.gov/cdc-%E2%80%94-influenza-deaths-request-...

(Table 1, down to 71) https://www.cdc.gov/nchs/nvss/vsrr/covid19/index.htm

We maxed out at 140% between 4/11 and 4/18/2020. One could try correlating that with the lockdowns.

Re:Increase in delirium, rare brain inflammation and stroke ... by throwaway_pdp09 on Wednesday July 08, 2020 @07:50AM (#23768962)
While I don't necessarily agree with this post (see below, plus I haven't had time to read your links properly), I don't see why it's downvoted - if there's a reason the downvoter should say why.

Anyway, I don't buy your reason for pneu & flu being on the same page, flu may be a subtype of pneumonia but there are many causes of pneumonia, and I don't expect flus to blow up into pneu. Then again, I'm just guessing.

Your second link is not official government statement - indeed it was so weird I didn't understand what I was reading at first - it's a letter expressing a person's opinion, not a government position. I don't know it's value.

The table's interesting, but the percentage of expected deaths don't make sense (read: I don't understand them). It may be down to time lag on reporting, but it's a big lag.

Anyway, well done for providing figures!

Re:Increase in delirium, rare brain inflammation and stroke ... by mattigames on Wednesday July 08, 2020 @01:54AM (#23767273)
As you know so far it has killed 133K people (out of 3000K infected) in the US alone, you consider this number not high enough to instate a "lockdown", so the question is what number would have been enough for one to be necessary according to you?
Re:Increase in delirium, rare brain inflammation and stroke ... by Jommi on Wednesday July 08, 2020 @02:54AM (#23767555)
That translates to around 0.4, which is in-line with normal influenza seasons.
Re:Increase in delirium, rare brain inflammation and stroke ... by panta on Wednesday July 08, 2020 @03:02AM (#23767597)
133k in 3000k is more like 4.4%, so an order of magnitude higher.
Re:Increase in delirium, rare brain inflammation and stroke ... by Jommi on Wednesday July 08, 2020 @03:09AM (#23767632)
Oops. Missed a zero, classically. So that does make it look more alarming. However could still be heavily effected by things such as low testing amounts, or vulnerable people front loading the numbers.
Re:Increase in delirium, rare brain inflammation and stroke ... by spaced-out on Wednesday July 08, 2020 @04:08AM (#23767905)
Deaths from Covid have already passed 100k, way more deaths than any flu season since those infamous pandemics, and that's despite lockdowns. No amount of fiddling with numbers changes that.
Re:Increase in delirium, rare brain inflammation and stroke ... by throwaway_pdp09 on Wednesday July 08, 2020 @04:58AM (#23768153)
> or vulnerable people front loading the numbers

So vulnerable people dying should not contribute to covid mortality statistics? Why is that?

Re:Increase in delirium, rare brain inflammation and stroke ... by Jommi on Wednesday July 08, 2020 @12:05PM (#23771218)
I mean that when we are in the middle of a pandemic most likely deaths are frontloaded in that those that are going to be affected the most, will most likely be the most effected by now. If that makes sense.

So it's more of a thing to keep in mind when comparing mortality statistics of an in progress pandemic to past pandemics.

Re:Increase in delirium, rare brain inflammation and stroke ... by ccozan on Wednesday July 08, 2020 @03:12AM (#23767650)
Nope. Is 0.4. check again.
Re:Increase in delirium, rare brain inflammation and stroke ... by j4yav on Wednesday July 08, 2020 @04:47AM (#23768100)
Hm, it really isn't, but you don't have to take my word for it.

https://www.percentagecal.com/answer/133-is-what-percent-of-...

Re:Increase in delirium, rare brain inflammation and stroke ... by Fjolsvith on Wednesday July 08, 2020 @01:20AM (#23767102)
"It is tempting to surmise that the complicated pandemic definitions used by the World Health Organization (WHO) and the Centers for Disease Control and Prevention of the United States of America involved severity in a deliberate attempt to garner political attention and financial support for pandemic preparedness." [1]

1. https://www.who.int/bulletin/volumes/89/7/11-088815/en/

Re:Increase in delirium, rare brain inflammation and stroke ... by jquery on Wednesday July 08, 2020 @01:23AM (#23767117)
I’m getting a little exhausted with doom and gloom that fails to contextualize exactly how much worse things are than an abnormally bad flu season + pneumonia season. If you tell people that they will have lingering effects from a flu or cold, they are much more likely to report lingering effects. People are quite suggestible and medicine is complex.
Re:Increase in delirium, rare brain inflammation and stroke ... by Godel_unicode on Wednesday July 08, 2020 @02:30AM (#23767433)
You seem to be implying that stroke can be psychosomatic. That's certainly a novel take.
Re:Increase in delirium, rare brain inflammation and stroke ... by jquery on Wednesday July 08, 2020 @10:45AM (#23770353)
That’s not what I was implying at all.