This is why I think the quote "All models are wrong, but some are useful" is so meaningful. Lots of bright eyed comp sci majors come into statstical genomics and bioinfomatics PhD programs every year, and all learn the hard lesson that wet lab still exists for a reason.

Not understanding your underlying conceptual model (be it biology here, or maybe healthcare, or natural resource exploration) will lead a lot of poor assumptions, limiting the impact of all the hard work.