If you're talking about trips of no more than a few miles (that don't include hauling too much cargo to carry), you can compare driving with walking. If you're talking about trips of tens or hundreds or thousands of miles, you have to compare driving with flying or taking a train.
I would be interested to see crash/injury/fatality stats for car trips under certain distance thresholds. I wonder if those are tracked anywhere.
Of course, part of the reason these crashes were newsworthy is that they were unusual. Are there enough takeoff- and landing- related losses to make these statistically irrelevant?
I didn't count them all, but from eyeballing it a 1000-mile journey is 3x as likely to kill you as a 100-mile one, not 1x or 10x.
[0] https://en.wikipedia.org/wiki/List_of_accidents_and_incident...