Meh. I'd say we're likely stuck in a local optimum - the default programming of our brains is clearly not optimal for our state of evolution... our brains evolved for hunting and gathering clearly don't have good default programming for understanding and exploring the universe.
Hope brain-computer-interfaces come soon and we can do more controlled hacks with those, but until then anything that can nudge our minds out of equilibrium / gradient-pit is great. And some side-effects (eg. small minority of people manifesting psychoses etc.) are a sign we're on the right track imo.
Sure, we can try tweaking external factors, sprinkling in some wars, terrorism, pandemics, riots etc. to occasionally wake some people up, our benevolent true leaders, whoever they are, treat us with these at least... but I'd support more direct and less destructive alternatives :)
Yes, this is exactly the take away one should take in my opinion.
Going into deep spiritual meaning about nature is a rabbit hole.
But - there is a reason we've evolved to perceive reality in this way. It allows us to survive. Material concerns - health, wealth, status etc. and extractive consumption which messes up "nature", and having ego/identity distinct from nature -- all of this serve useful, vital purposes. A person who's constantly tripping will find it difficult to survive both in modern and ancient times long enough to propagate their genes.
People search for profundity in these experiences, and sure there are some. But to really understand the world and nature, I think the lens of science - observation, empiricism, and the scientific process is a better bet. There unfortunately really isn't anything _deeper_ about life. And whatever there is, personal introspection aided by psychedelics cannot hold a candle against organized human scientific endeavor.
Also, messing with one's brain is dangerous. It is one of the least understood human organs, irreplaceable, and fundamental to life like few other things.