Another major benefit of pen on paper is it's far less tiring, at least for me. I find staring at screens for extended periods utterly draining and often use paper for notes and code reading.

Major disadvantages - lack of relatively easy search, security, duplication, archiving, integration, accessibility to others, etc.

So it's a complementary tool for me, but the digital-only brigade are missing a useful, and - vital to some - dimension.