For games, I've found using wine though Lutris (https://lutris.net/) to be mostly frustration-free. To avoid the need to toy around trying to find a configuration of wine version, dlls to add/override/etc., and other settings that wine provides, Lutris provides a "recipes" for creating an environment that someone has verified works for the given application. It has a lot of recipes for non-gaming applications as well, although I haven't used it for much of that personally.