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Re:Deno 1.0 by williamdclt on Wednesday May 13, 2020 @06:59PM (#23172863)
AFAIK, tsc is just a compiler, not a runtime. Once you compiled, you're just executing javascript so it only impacts startup time.

ts-node is a runtime able to run TypeScript. It is definitely much much slower at execution, not just at startup time. It's useful for hacking around, I use it as a REPL but even for a dev environment it's faster to use tsc's incremental compilation with a file watcher, and execute the resulting JS

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