It took a good deal of fiddling but I was able to get this starter project working with Valve Index: https://www.unrealengine.com/marketplace/en-US/product/steam...

It included teleporting and picking up objects, full hand tracking and finger positioning.

Overall, it seemed like a decent foundation but clearly needed a LOT of work to be ready for a full game. The skillset and toolset is very different than what web/app devs and backend devs use.