I mean, you're not forced to service foreign nations. But if you are trading with foreign nations, then you've got to realize that that is fundamentally a voluntary relationship—trade doesn't exist by default, it is created by a spirit of mutual cooperation, on a foundation of compromise. If that spirit of cooperation and foundation of compromise don't exist, then the trade cannot exist.

Or, to put that another way: WIPO itself is something the US "forced" on the rest of the world. But it wasn't actually force; it was just a condition on other nations continuing to trade with the US.

As I said, taking your ball and going home should be an option. That implies NOT trading with EU.

As per wiktionary.org: "To cease participating in an activity that has turned to one's disadvantage, especially out of spite, or in a way that prevents others from participating as well."

You are assuming a point I did not make.

You mean like EU companies are not forced to stop trading with Iran, it was their free decision.

Yes, I believe Iran sanctions function similarly to WIPO, the US requires people to follow certain rules if they want to do business with the US.

Just block EU IP addresses if you want. No-one is forcing you to allow access to any particular country or region.

Doesn't make a difference. If I access your site as a EU citizen through a VPN, then you must follow GDPR.

Honestly I'm not sure about what the outcome is there, has it ever been tested?