I went from Laravel (PHP) to Symfony (PHP) to Flask (Python), and Django (Python). Django feels the best to build medium-big stuff quickly, but all of the ones mentioned above are decent. Frontend-wise Angular feels too bloated, Vue.js 2 is nice (waiting for v3), but looking into Svelte and feeling excited about it.

CSS I'm comfortable with Bootstrap and Bulma, but want to look into Tailwind for future projects.