Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by shadowgovt on Wednesday April 15, 2020 @01:44PM
(#22880711)
Question: are the induced arrhythmias permanent or do they discontinue when HCQ therapy discontinues?
I'm curious as to the permanency of the damage.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by epmaybe on Wednesday April 15, 2020 @01:48PM
(#22880749)
the qt prolongation of heart rhythm goes away once discontinued.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by jamesblonde on Wednesday April 15, 2020 @05:50PM
(#22883500)
Qt prolongation does not mean you have arrhythmias. You don't get tachycardia or atrial flutter or necessarily sympthoms. Clinically if it means there is a risk if the QT interval gets to long that you will have a fatal arrhythmia - torsades de pointes. So you need to know how bad the Qt prolongation is. In the paper 2 patients had serious side effects - one with QT prolongation over 500ms and the second with a first-degree atrioventricular block. Another maybe had a left bundle branch (not great, but not fatal). They resolved by stopping HCQ treatment.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by epmaybe on Wednesday April 15, 2020 @07:07PM
(#22884215)
I didn't claim that the QT prolongation implied arrhythmia.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by DataWorker on Wednesday April 15, 2020 @01:41PM
(#22880668)
Wouldn’t ecg changes be plausibly the result of the virus itself? I haven’t read the paper so maybe they go into greater detail but it would be important to know whether such changes were seen in the control group as attrition/discontinuance is critically important to any study.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by CydeWeys on Wednesday April 15, 2020 @01:49PM
(#22880767)
Well they're the most frequently occurring serious side effect of HCQ, so I'm not sure why you're leaping to blame the virus when the drug they're giving is well-known for causing exactly those problems.
Those ECG changes aren't generally observed just in people who have COVID-19; it's the drug that we know does that, doing that.
Re:Study: No evidence of efficacy of hydroxychloroquine in h...
by mullingitover on Wednesday April 15, 2020 @02:33PM
(#22881292)
I imagine this question would be sorted out by looking at the control group.
"In the weighted analysis, 20.2% patients in the HCQ group were transferred to the ICU or died within 7 days vs 22.1% in the no-HCQ group (16 vs 21 events, relative risk [RR] 0.91, 95% CI 0.47-1.80)."
And...
"Eight patients receiving HCQ (9.5%) experienced electrocardiogram modifications requiring HCQ discontinuation."