Yup. I work in robotics.
I try to isolate the actual hardware interaction layer so that for testing you can mock the driver and hardware in one piece. Of course that does not test the driver. With any luck, the driver is pretty stable once it works, though. And the driver+hardware piece can have it's own (physical) test bench so that at least manual testing is, well maybe not efficient, but at least not painful.
Simulators are great but not always available. Or are too much work to get going.
One configuration often used for robots is the "boneless chicken". Take a bench, and bolt all the guts down to it in a configuration where they are easy to probe. Put the wheel motors someplace safe, with a synthetic load like a pony brake. Of course you can't test the nav stack that way. (I once interviewed a firmware engineer who was coming off of the Juicero shutdown -- say what you want about Juicero, but from the sounds of it their boneless chicken was outstanding, even integrated into the CI automation pipeline. Of course, they didn't have the nav problem).
Speaking of nav, I once saw a warehouse robot company's nav PR test micro-warehouse. Not the full test warehouse, just a 500 square foot or so area dedicated to testing nav PR's. It was integrated with CI automation. I could tell from the accumulated tire marks on the floor that they had nav pretty much nailed.
I have done several robot-to-elevator interfaces (probably more than anyone else). In the end, final testing always required something akin to a few midnight to 4 AM test blocks on the real elevator. And then of course as you point out:
> the whole system has a ton of potential interactions that are hard to write test cases for.
They often don't show up until the system is under load.
When I'm testing thermal cameras there are a sequence of things I can check to ensure that the test worked: was the command sent without errors? Did I get an error back from the camera (e.g. CRC failure)? Does the state of the camera change as I expect it to? If all of those things are correct then the likelihood is that the command sent OK. Of course for states you should check various permutations (e.g. shutter open and shutter closed) to make sure that you don't have a bug in your state reading code :)
Here's a stereo matching example from OpenCV. This is a case when you do have the correct answer, but you don't expect to equal it, and your tolerance to accuracy varies with algorithm:
https://github.com/opencv/opencv/blob/055645080161c6af6083b6...
The OpenCV example is a pretty easy one. You have clear inputs with clearly defined outputs. The only thing you have to do is to create sample data.