> In contrast, the “Mary’s room” scenario tells us nothing useful and has no connection to the real world, because it’s not actually about the physics or physiology of colour at all.

But it could be. One materialist response to Mary's room actually disputes the physicality of the entire arrangement. Consider that in order for Mary to be able to answer any question about the optical system of the human brain, she would have to be able to answer nearly every question possible; it requires ungodly amounts of data and computing power from the quantum level and up.

That amount of information in a finite space would collapse into a black hole, per the Bekenstein Bound, so Mary's room is actually incoherent at its core. You can see shade's of this in Dennett's response to Mary's room.