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A comment on SARS-CoV-2 titers in wastewater are higher than expected from confirmed cases. Parent comment

Re:SARS-CoV-2 titers in wastewater are higher than expected ... by mannykannot on Friday April 10, 2020 @10:27AM (#22833327)
I realize that your comment is tongue-in-cheek, but if the situation were so (or just if there are a great many asymptomatic cases), then the continuing rapid increase of symptomatic cases would indicate something rather unusual, including, if I am not mistaken, little immunity, in many cases, from a first infection, and second infections being more serious than the first. I vaguely think that there are some diseases like this (or perhaps I am just thinking of allergen sensitization.)
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Re:SARS-CoV-2 titers in wastewater are higher than expected ... by cesarb on Friday April 10, 2020 @10:49AM (#22833559)
> and second infections being more serious than the first. I vaguely think that there are some diseases like this (or perhaps I am just thinking of allergen sensitization.)

You might be thinking of dengue (which is endemic in my home region). There are four strains of the dengue virus; if you are infected by one strain, and had in the past been infected by a different strain, it increases the risk of the more serious hemorrhagic dengue.

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Re:SARS-CoV-2 titers in wastewater are higher than expected ... by mannykannot on Friday April 10, 2020 @11:12AM (#22833816)
Thanks, that is interesting. As far as I know, we are only dealing with one strain here, though there have been enough mutations that it is clear that most cases in New York came via Europe.

https://www.nytimes.com/2020/04/08/us/coronavirus-live-updat...

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Re:SARS-CoV-2 titers in wastewater are higher than expected ... by jhayward on Friday April 10, 2020 @06:30PM (#22837991)
Yes, this is Antibody Dependent Enhancement[1], which is also something that any vaccine will have to rule out through human trials. These sorts of immune system traps and pitfalls are why vaccine testing takes so long.

[1] https://en.wikipedia.org/wiki/Antibody-dependent_enhancement

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Re:SARS-CoV-2 titers in wastewater are higher than expected ... by ficklepickle on Friday April 10, 2020 @02:29PM (#22835952)
My dad caught dengue. It was nasty. Fortunately not the hemmorhagic variety. It's at least as scary as malaria, but with much less research devoted to it.
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Re:SARS-CoV-2 titers in wastewater are higher than expected ... by eternauta3k on Friday April 10, 2020 @10:43AM (#22833497)
Dengue is like this, second infection is really bad.
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