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A comment on Man dies after self-medicating with chloroquine. Parent comment

Re:Man dies after self-medicating with chloroquine by pbreit on Monday March 23, 2020 @07:47PM (#22670196)
It's been confirmed effective against SARS CoV in vitro [1]. Before you say it, yes, I know treatments in vitro do not always work in vivo.

Reports from China, South Korea and France have suggested efficacy in humans against COVID-19.

1: https://www.ncbi.nlm.nih.gov/pubmed/15351731

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Re:Man dies after self-medicating with chloroquine by et2o on Monday March 23, 2020 @07:50PM (#22670217)
Actually they rarely translate.

Chloroquine is a particularly funny example because they have already tried it as an antiviral drug several times without any efficacy.

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Re:Man dies after self-medicating with chloroquine by pbreit on Tuesday March 24, 2020 @12:39AM (#22672000)
Can you point to evidence that in vitro efficacy rarely translates to in vivo?

I've seen the one situation of chloroquine showing promise in vitro against SARS CoV but no others. Is there literature on others?

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