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A comment on Chloroquine has shown apparent efficacy in treatment of Covid-19. Parent comment

Re:Chloroquine has shown apparent efficacy in treatment of C... by signa11 on Tuesday March 17, 2020 @02:02AM (#22602172)
> ... has a cumulative dose of more than 1000 grams. ...

woowza a Kg worth of drug !!! this doesn't look correct to me !

[ Parent | on HN ]
Re:Chloroquine has shown apparent efficacy in treatment of C... by fspeech on Tuesday March 17, 2020 @02:37AM (#22602351)
This drug accumulates in various tissues, so for retinopathy what matters is the cumulative amount of the drug consumed over time.
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Re:Chloroquine has shown apparent efficacy in treatment of C... by signa11 on Tuesday March 17, 2020 @04:52AM (#22602987)
oh man ! just like excess of vitamin-d can lead to vitamin-d toxicity, so can this. in my naïveté, i was assuming that excess of it would be just flushed out.
[ Parent | on HN ]
Re:Chloroquine has shown apparent efficacy in treatment of C... by fspeech on Tuesday March 17, 2020 @12:43PM (#22606817)
Its concentration in lung can be 100 times or more of that in serum. This may be helpful for its efficacy against the virus.
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Re:Chloroquine has shown apparent efficacy in treatment of C... by Johnny555 on Tuesday March 17, 2020 @02:10AM (#22602212)
People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity

400mg/day for 5 years is 730 grams.

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Re:Chloroquine has shown apparent efficacy in treatment of C... by majkinetor on Tuesday March 17, 2020 @02:56PM (#22608736)
only if everything gets stored, and there is no chance for that
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Re:Chloroquine has shown apparent efficacy in treatment of C... by Johnny555 on Tuesday March 17, 2020 @03:43PM (#22609406)
The risk is for cumulative (not accumulated) dose:

has a cumulative dose of more than 1000 grams

And the calculator they link out to gives the same number I calculated.

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Re:Chloroquine has shown apparent efficacy in treatment of C... by reitzensteinm on Tuesday March 17, 2020 @02:12AM (#22602220)
A kg isn't necessarily that much over a lifetime. I'm over that with at least one drug.
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Re:Chloroquine has shown apparent efficacy in treatment of C... by javiermares on Tuesday March 17, 2020 @06:23AM (#22603492)
taken over the years
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