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Re:2019-nCoV may contain a gain-of-function for efficient sp... by fxtentacle on Tuesday March 10, 2020 @11:49AM (#22536464)
They talk about a "cleavage site", meaning a 3D shape with the chemical properties necessary to cut something. And apparently, that ability to cut molecules similar to furin enables this virus to more efficiently enter cells, i.e. successfully infecting someone with a lower dose of live viruses.

Where this new shape came from, they do not know. But since viruses tend to mutate a lot and integrate RNA snippets floating around in their host's blood stream, it is likely that they picked it up from some other virus simultaneously infecting the same individual.

In short, the new nCoV seems to be so contagious because it merged in a new feature from a different virus species.

The implication is that by specifically blocking this thing that nCov has but older Cov do not have, one might be able to drastically reduce its contagiousness.

Re:2019-nCoV may contain a gain-of-function for efficient sp... by otherme123 on Tuesday March 10, 2020 @12:25PM (#22536848)
The analysis they present doesn't require the integration of foreign RNA. 2019nCov has a SPRR motif, where other viruses has similar motifs (SRRK, KNRR, TPRS...). It can be explained with mutations, and in fact they talk about convergent evolution.
Re:2019-nCoV may contain a gain-of-function for efficient sp... by scrozier on Tuesday March 10, 2020 @12:12PM (#22536693)
Small elaboration: it didn’t “merge in” this feature, it independently evolved it (“convergent evolutionary pathway”), which implies it’s a particularly handy feature for this virus to have. (For the virus, not so much for us.)
Re:2019-nCoV may contain a gain-of-function for efficient sp... by fabian2k on Tuesday March 10, 2020 @12:00PM (#22536579)
The cleavage site is the target that gets cleaved, not the part that does the cutting. So in this case the virus has a site that can be cleaved by certain enzymes like Furin.
Re:2019-nCoV may contain a gain-of-function for efficient sp... by gazsp on Tuesday March 10, 2020 @12:04PM (#22536613)
Re:2019-nCoV may contain a gain-of-function for efficient sp... by webdevatlurk on Tuesday March 10, 2020 @12:01PM (#22536582)
From the Wiki page for Furin

> ...must be cleaved by furin or furin-like proteases to become fully functional. Anthrax toxin, pseudomonas exotoxin, and papillomaviruses must be processed by furin during their initial entry into host cells.

From the sound of this:

- the site on the virus gets cleaved - Furin enables the cleaving - Furin exists in hosts cells

What I think I understand is, the cleaving makes it easier for the virus to reproduce inside the cell?

edit: turns out I have no idea how to format things on HN

Re:2019-nCoV may contain a gain-of-function for efficient sp... by rolph on Tuesday March 10, 2020 @12:05PM (#22536629)
the cleaving prepares the virus to be able to enter the cell