I'm fortunate enough to have the space in my 3/1 1140sqft SV home for a desk and desktop computer and the like. Basically, it's giving up a bedroom, although of course the computer does not take up the entire room. Thankfully, we don't have kids, so it's not an issue, but it's a non-zero cost, particularly if you're renting.

OTOH, of course, someone will come along to point out that you can afford 20 spare bedrooms if you work remote and can move from SV to a farm in upstate NY.