It's also a counterpoint to one of the OP's points which is that trying to secure email is a dead-end that we should give up on. It may be possible, though very difficult, to transition to secure email. But it would have to be a brand new protocol not tacked-on to the current system. The way that SFTP is the appropriate upgrade path for FTP and not FTPS.
A new e2e protocol that works just like email does would be excellent, but we don't yet have that. Signal &co are chat apps with a different feel and purpose and other than matrix and xmpp not federated, which is a non starter for many entities.
There are some things we could easily give up to get encrypted mail. For example, setting a max delivery time to allow ephemeral keys.
But there are other problems with encrypted messaging, and I'm particularly thinking of spam. How does Signal/WhatsApp manage to keep a lid on it? Would that be possible in a federated system?