"In fact, the most widely accepted treatment of chronic typhoid infection is removal of the gallbladder."
And, in particular, it looks like the most chronic and asymptomatic (like Typhoid Mary) have biofilms on gallstones that serves as a very difficult to kill reservoir.
Quoting https://www.sciencedaily.com/releases/2010/02/100222162004.h...:
"In fact, the most widely accepted treatment of chronic typhoid infection is removal of the gallbladder."
And, in particular, it looks like the most chronic and asymptomatic (like Typhoid Mary) have biofilms on gallstones that serves as a very difficult to kill reservoir.