I used to run Gentoo. At one point, trying to resolve dependency conflicts, and not knowing what I was trying to do, I uninstalled libc. Obviously, my system immediately became unusable.

I actually appreciate that Gentoo is set up to allow me to run that command if I want to.

But I did move off of Gentoo due to constant dependency conflicts. They took forever to deal with and they were pretty well guaranteed to happen whenever you didn't hold to a strict and frequent update schedule.