If I'm filling in the blanks here correctly, what we're still far away from is determining the folded configuration of an arbitrary polypeptide. Is that correct? Or has there been real breakthroughs there? 10 years ago when I last checked in with some folk I knew from EMBL, this still seemed to be a complete pipedream.

Is there a paper that describes the parameters of the peptide structure that go into the "physics do the folding" part? When I was at EMBL, I was focused on using local hydrophobicity to see how predictive it was (not at all). Is the physics model operating at this level, above it, or below it?